Do not take more or less of it or take it more often than prescribed by your doctor. You should begin to feel better during the first few days of treatment with co-trimoxazole.
If your symptoms do not improve or if they get worse, call your doctor. Take co-trimoxazole until you finish the prescription, even if you feel better. Do not stop taking co-trimoxazole without talking to your doctor. If you stop taking co-trimoxazole too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.
This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule.
Do not take a double dose to make up for a missed one. Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture not in the bathroom. It is important to keep all medication out of sight and reach of children as many containers such as weekly pill minders and those for eye drops, creams, patches, and inhalers are not child-resistant and young children can open them easily.
To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location — one that is up and away and out of their sight and reach.
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. In case of overdose, call the poison control helpline at If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at Keep all appointments with your doctor and the laboratory.
Your doctor will order certain lab tests to check your response to co-trimoxazole. Nucleoside Reverse Transcriptase Inhibitor abacavir, lamivudine, zidovudine. Nucleoside Reverse Transcriptase Inhibitor emtricitabine, tenofovir alafenamide. Nucleoside Reverse Transcriptase Inhibitor lamivudine. Nucleoside Reverse Transcriptase Inhibitor lamivudine, zidovudine.
Nucleoside Reverse Transcriptase Translocation Inhibitors. Pharmacokinetic Enhancer cobicistat. Pharmacokinetic Enhancer ritonavir. Post-attachment Inhibitor. Protease Inhibitors PIs. Protease Inhibitor atazanavir. Protease Inhibitor darunavir. Protease Inhibitor lopinavir. Skin and Mucus Membrane Products. Therapeutic Vaccines. Bacterial Enteric Infections. Mucocutaneous Candidiasis. Cytomegalovirus Disease. Disseminated Mycobacterium avium Complex Disease.
Toxoplasma gondii Encephalitis. Human Herpesvirus-8 Diseases. Herpes Simplex Virus Disease. Varicella-Zoster Virus Diseases. Hepatitis B Virus Infection. Hepatitis C Virus Infection.
Herpes Zoster. Pneumocystis Pneumonia. Penicilliosis marneffei. Drug information Audio. Your browser does not support the audio element. Other Names:. Drug Class:. Chemical Image: Click to enlarge.
Pharmacokinetics in Geriatric Patients The pharmacokinetics of sulfamethoxazole mg and trimethoprim mg were studied in 6 geriatric subjects mean age: Resistance In vitro studies have shown that bacterial resistance develops more slowly with both sulfamethoxazole and trimethoprim in combination than with either sulfamethoxazole or trimethoprim alone.
Urinary Tract Infections For the treatment of urinary tract infections due to susceptible strains of the following organisms: Escherichia coli , Klebsiella species, Enterobacter species, Morganella morganii , Proteus mirabilis and Proteus vulgaris.
Acute Otitis Media For the treatment of acute otitis media in pediatric patients due to susceptible strains of Streptococcus pneumoniae or Haemophilus influenzae when in the judgment of the physician sulfamethoxazole and trimethoprim offers some advantage over the use of other antimicrobial agents.
Acute Exacerbations of Chronic Bronchitis in Adults For the treatment of acute exacerbations of chronic bronchitis due to susceptible strains of Streptococcus pneumoniae or Haemophilus influenzae when a physician deems that BACTRIM could offer some advantage over the use of a single antimicrobial agent.
Shigellosis For the treatment of enteritis caused by susceptible strains of Shigella flexneri and Shigella sonnei when antibacterial therapy is indicated. Pneumocystis jirovecii Pneumonia For the treatment of documented Pneumocystis jirovecii pneumonia and for prophylaxis against P. Traveler's Diarrhea in Adults For the treatment of traveler's diarrhea due to susceptible strains of enterotoxigenic E.
Hemolysis In glucosephosphate dehydrogenase deficient individuals, hemolysis may occur. Impaired Phenylalanine Metabolism The trimethoprim component of BACTRIM has been noted to impair phenylalanine metabolism, but this is of no significance in phenylketonuric patients on appropriate dietary restriction. Electrolyte Abnormalities Hyperkalemia : High dosage of trimethoprim, as used in patients with P. Information for Patients Patients should be counseled that antibacterial drugs including Bactrim sulfamethoxazole and trimethoprim tablets should only be used to treat bacterial infections.
Methotrexate Avoid concurrent use Sulfonamides can also displace methotrexate from plasma protein binding sites and can compete with the renal transport of methotrexate, thus increasing free methotrexate concentrations. Cyclosporine Avoid concurrent use There have been reports of marked but reversible nephrotoxicity with coadministration of BACTRIM and cyclosporine in renal transplant recipients. Indomethacin Avoid concurrent use Increased sulfamethoxazole blood levels may occur in patients who are also receiving indomethacin.
Pyrimethamine Avoid concurrent use Occasional reports suggest that patients receiving pyrimethamine as malaria prophylaxis in doses exceeding 25 mg weekly may develop megaloblastic anemia if BACTRIM is prescribed. Angiotensin Converting Enzyme Inhibitors Avoid concurrent use In the literature, three cases of hyperkalemia in elderly patients have been reported after concomitant intake of BACTRIM and an angiotensin converting enzyme inhibitor.
Mutagenesis In vitro reverse mutation bacterial tests according to the standard protocol have not been performed with sulfamethoxazole and trimethoprim in combination. Pregnancy While there are no large, well-controlled studies on the use of sulfamethoxazole and trimethoprim in pregnant women, Brumfitt and Pursell, 11 in a retrospective study, reported the outcome of pregnancies during which the mother received either placebo or sulfamethoxazole and trimethoprim.
Teratogenic Effects Human Data While there are no large prospective, well controlled studies in pregnant women and their babies, some retrospective epidemiologic studies suggest an association between first trimester exposure to sulfamethoxazole and trimethoprim with an increased risk of congenital malformations, particularly neural tube defects, cardiovascular abnormalities, urinary tract defects, oral clefts, and club foot.
Geriatric Use Clinical studies of BACTRIM did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Psychiatric: Hallucinations, depression, apathy, nervousness. Musculoskeletal: Arthralgia, myalgia, rhabdomyolysis.
Miscellaneous: Weakness, fatigue, insomnia. The total daily dose should not exceed mg sulfamethoxazole and mg trimethoprim. J Clin Pharmacol. Feb-Mar ; — Kaplan SA, et al. Pharmacokinetic Profile of Trimethoprim-Sulfamethoxazole in Man. J Infect Dis. Nov ; Suppl : S—S Varoquaux O, et al.
Pharmacokinetics of the trimethoprim-sulfamethoxazole combination in the elderly. Br J Clin Pharmacol. Adjunctive folinic acid with trimethoprim-sulfamethoxazole for Pneumocystis carinii pneumonia in AIDS patients is associated with an increased risk of therapeutic failure and death. Marinella Mark A. Trimethoprim-induced hyperkalemia: An analysis of reported cases.
Margassery, S. Life threatening hyperkalemia and acidosis secondary to trimethoprim-sulfamethoxazole treatment. Moh R, et al. Antivir Ther. Review: The Pharmacology and Toxicology of Dofetilide. Int J Med Toxicol. Trimethoprim alters the disposition of procainamide and N- acetylprocainamide.
Clin Pharmacol Ther. Oct ;44 4 Brumfitt W, Pursell R. Masur H. Prevention and treatment of Pneumocystis pneumonia. N Engl J Med. Recommendations for prophylaxis against Pneumocystis carinii pneumonia for adults and adolescents infected with human immunodeficiency virus. CDC Guidelines for prophylaxis against Pneumocystis carinii pneumonia for children infected with human immunodeficiency virus.
Distributed by: Sun Pharmaceutical Industries, Inc. Cranbury, NJ Rev. Labeler - Sun Pharmaceutical Industries, Inc Drug s. Avoid concurrent use. Monitor prothrombin time and INR. Monitor serum phenytoin levels. Monitor serum digoxin levels. Tricyclic Antidepressants TCAs. Monitor therapeutic response and adjust dose of TCA accordingly. Monitor blood glucose more frequently. Angiotensin Converting Enzyme Inhibitors. This site complies with the HONcode standard for trustworthy health information: verify here.
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